Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/heparin antibodies devel...

Heparin-induced Thrombocytopenia

Nebojša M. Antonijević1, Nebojša Radovanović1, Slobodan Obradović2, Dragica Vučelić6, Bojan Stojanović1, Danijela Miković4, Mirjana Kovač4, Tina Kočica1, Svetlana Tadić4, Irina Antonijević4, Snežana Drašković4, Valentina Djordjević5, Branko Čalija6, Jovan Peruničić1, Zorana Vasiljević1 1 Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia; 2 Clinic of Emergency Med...

Heparin-induced thrombocytopenia.

Each year, 25% of all hospitalized patients are affected by venous thromboembolism, a disease comprising deep vein thrombosis and pulmonary embolism, that is responsible for up to 10% of all inpatient deaths (Alikhan, Peters, Wilmott, Cohen, 2004). Used in both the treatment and the prevention of venous thromboembolism, heparin is administered to more than 12 million patients each year in the U...

Heparin-Induced Thrombocytopenia

1 Shindo Y, Sato S, Maruyama E, et al. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest 2009; 135:633–640 2 Teramoto S, Yamamoto H, Yamaguchi Y, et al. Lower respiratory tract infection outcomes are predicted better by an age 80 years than by CURB-65. Eur Respir J 2008; 31:477–478 3 Teramoto S, Fukuchi Y, Sasaki H, et al. High incidence of asp...

Heparin-Induced Thrombocytopenia